The antimetabolite 3-bromopyruvate selectively inhibits Staphylococcus aureus
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چکیده
منابع مشابه
Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.
Neutrophils play a central role in the innate immune response and a critical role in bacterial killing. Most studies of neutrophil function have been conducted under conditions of ambient oxygen, but inflamed sites where neutrophils operate may be extremely hypoxic. Previous studies indicate that neutrophils sense and respond to hypoxia via the ubiquitous prolyl hydroxylase/hypoxia-inducible fa...
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ژورنال
عنوان ژورنال: International Journal of Antimicrobial Agents
سال: 2019
ISSN: 0924-8579
DOI: 10.1016/j.ijantimicag.2018.11.008